A 53-year-old woman with a history of coccidioidal meningitis discontinued her long-term suppressive fluconazole following normal head computed tomography (Figure 1A) and cerebrospinal fluid evaluation. Four months later, she presented with gait instability, confusion, and headache. Computed tomography of the head demonstrated hydrocephalus (Figure 1B) and magnetic resonance imaging of the brain showed extensive vasogenic edema and meningeal enhancement (Figure 2). Results of cerebrospinal fluid evaluation were consistent with fungal infection and positive for the coccidioidal antibody.