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Comment & Response
May 2014

DCTN1 Mutations and Progressive Supranuclear Palsy–Like Phenotype

Author Affiliations
  • 1Department of Neurology, Mayo Clinic, Jacksonville, Florida
JAMA Neurol. 2014;71(5):655. doi:10.1001/jamaneurol.2014.227

To the Editor We recently read the article by Caroppo et al1 with interest, and we congratulate them for their excellent work. Caroppo et al1 analyzed 19 families in which affected individuals presented with atypical parkinsonism and a progressive supranuclear palsy (PSP)–like phenotype. They also identified a DCTN1 G71E mutation in 4 of the affected patients; all were from a single French family. The mutation was reported previously in another French family.2