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Comment & Response
June 2014

Medulloblastoma and Dizziness

Author Affiliations
  • 1Department of Surgery, University of Santiago de Compostela, Santiago de Compostela, Spain
JAMA Neurol. 2014;71(6):801. doi:10.1001/jamaneurol.2014.173

To the Editor We read with interest the article by Shu et al1 and we would like to make the following observations on the basis of our personal experience.

Medulloblastoma is a primitive neuroectodermal tumor and about 50% of these tumors occur in children aged younger than 5 years, whereas they are rare in adolescents and young adults. Medulloblastoma behaves differently in adults than in children and is identified as a different biological and clinical entity. It exhibits a higher proportion of desmoplastic histologic characteristics than childhood medulloblastoma and shows a higher incidence within the cerebellar hemispheres, thus featuring different proliferative and apoptotic indices and having a tendency for late relapse.2