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Comment & Response
July 2014

Features of Neuromyelitis Optica Spectrum Disorders With Aquaporin-4 and Myelin-Oligodendrocyte Glycoprotein Antibodies

Author Affiliations
  • 1Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China
  • 2Department of Neurology, The Second Part, The First Hospital of Jilin University, Changchun, China
  • 3School of Public Health, Jilin University, Changchun, China
JAMA Neurol. 2014;71(7):923-924. doi:10.1001/jamaneurol.2014.764

To the Editor In their article, Kitley and colleagues1 characterized the features of patients with neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSDs) with myelin-oligodendrocyte glycoprotein antibodies (Abs) and compared them with patients with aquaporin-4 antibody (AQP4-Ab)–positive NMO/NMOSD. They found that patients with myelin-oligodendrocyte glycoprotein Abs who fulfilled the diagnostic criteria for NMO were different from those with AQP4-Abs in terms of sex preponderance, age distribution, and involvement of conus and deep gray matter structures on imaging, as well as outcomes.1