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Comment & Response
September 2014

Relevance of CD34+ Cells as a Reservoir for JC Virus in Patients With Multiple Sclerosis

Author Affiliations
  • 1Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany
  • 2Institute for Virology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany
JAMA Neurol. 2014;71(9):1192. doi:10.1001/jamaneurol.2014.1855

To the Editor With interest we read the article by Frohman and coauthors,1 contrasting our own findings. As previously reported, we failed to detect JC virus (JCV) DNA in peripheral mononuclear cells (PBMCs), CD34+ hematoprogenitors, and bone marrow.2,3 We might have missed the low levels of JCV DNA reported by Frohman and coauthors owing to an 8-fold-lower total blood volume available in our study.2 Recently, another study confirmed the observation of JCV DNA in PBMCs, including the CD34+ subset,4 favoring PBMCs as a reservoir for JCV. Nevertheless, to our understanding, it remains unclear whether PBMCs or CD34+ cells represent a relevant reservoir.

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