[Skip to Navigation]
December 2014

Possible Role of Orexin in the Pathogenesis of Alzheimer Disease

Author Affiliations
  • 1Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy
JAMA Neurol. 2014;71(12):1478-1480. doi:10.1001/jamaneurol.2014.2819

Alzheimer disease (AD) is a current and growing public health problem that really has minimally effective therapies. Even a modest reduction in the risk of AD would have a tremendous public health impact. Interestingly, sleep disturbances are multifaceted and represent an early component of AD. The severity of sleep disruption appears to parallel the severity of dementia.1

Add or change institution