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December 2014

Possible Role of Orexin in the Pathogenesis of Alzheimer Disease

Author Affiliations
  • 1Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy
JAMA Neurol. 2014;71(12):1478-1480. doi:10.1001/jamaneurol.2014.2819

Alzheimer disease (AD) is a current and growing public health problem that really has minimally effective therapies. Even a modest reduction in the risk of AD would have a tremendous public health impact. Interestingly, sleep disturbances are multifaceted and represent an early component of AD. The severity of sleep disruption appears to parallel the severity of dementia.1