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Comment & Response
April 2015

Vaccination, Infection, and the Risk for Multiple Sclerosis

Author Affiliations
  • 1Georg August University, Goettingen, Germany
  • 2London Clinic Cancer Centre B2, London, England
JAMA Neurol. 2015;72(4):480. doi:10.1001/jamaneurol.2014.4708

To the Editor In an article in JAMA Neurology, Langer-Gould et al1 investigated a possible long-term detrimental effect of vaccinations on the risk for multiple sclerosis (MS). The authors put particular emphasis on vaccines against hepatitis B and human papillomaviruses that had previously been associated with the acute onset of central nervous system–demyelinating disease. The good news is that there are no long-term detrimental effects of any kind of the vaccination investigated, although there was an association with any form of vaccination and the onset of demyelinating disease within 30 days of vaccination in younger individuals. This is thought to be owing to an acceleration of disease being already in the stage of development, as a similar relationship had been described between MS risk and infections.