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June 2015

Cognition and Quality-of-Life Outcomes in the Targeted Temperature Management Trial for Cardiac Arrest

Author Affiliations
  • 1Departments of Neurological Surgery and Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas
  • 2Departments of Neurology, Neurosurgery, Anesthesiology, and Occupational Therapy, Washington University School of Medicine, St Louis, Missouri
JAMA Neurol. 2015;72(6):628-630. doi:10.1001/jamaneurol.2015.0164

The last decade has witnessed significant advances in the management of patients with cardiac arrest (CA), resulting in improvement in survival and functional outcome. An analysis of data from the Cardiac Arrest Registry to Enhance Survival, a prospective registry of patients with out-of-hospital CA, found that risk-adjusted rates of survival to hospital discharge in the United States increased from 5.7% in 2005-2006 to 8.3% in 2012, with a concomitant improvement in neurologic outcomes among survivors.1 Denmark, the United Kingdom, and Japan have also reported similar trends.2-4 Improved survival has been attributed to implementation of the 2005 American Heart Association guidelines for cardiopulmonary resuscitation, increase in bystander cardiopulmonary resuscitation rates, and the use of automated external defibrillators.4-6