The French neurologist Jean-Marie Charcot (1825-1893) is acclaimed for his studies on the motor system and unifying previously disparate entities into 1 disorder, amyotrophic lateral sclerosis (ALS). His careful work correlating neurological signs with anatomy led to the concept that a spectrum of neurological disorders, including progressive muscular atrophy, progressive bulbar palsy, and primary lateral sclerosis, represented a single entity, ALS. Charcot summarized his ideas in a frequently cited review in 1874 that has dominated medical nosology for 140 years.1
Goutman SA, Feldman EL. Clinical Trials of Therapies for Amyotrophic Lateral Sclerosis: One Size Does Not Fit All. JAMA Neurol. 2015;72(7):743–744. doi:10.1001/jamaneurol.2014.4275
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.