The field of multiple sclerosis (MS) has benefited immensely from brain magnetic resonance imaging (MRI) scans as a biomarker of white matter inflammatory lesions. Magnetic resonance imaging has become an essential component of clinical practice to confirm diagnosis, identify new therapies, stratify disease severity, and monitor treatment response. Nearly 30 years ago, the discovery of white matter plaques fascinated the field and sparked a revolution toward understanding this disease. Initially, these MRI bright spots were met with some skepticism because early investigations suggested a murky relationship between T2-weighted signal changes and clinical outcomes.
Naismith RT. Cortical Lesions in Multiple Sclerosis: Clinical Relevance for a Hidden Disease Burden. JAMA Neurol. 2015;72(9):979–980. doi:https://doi.org/10.1001/jamaneurol.2015.1422
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