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Comment & Response
December 2015

Insulin Resistance and APOE ε4

Author Affiliations
  • 1Iowa State University, Ames
  • 2US Department of Veterans Affairs, Albuquerque, New Mexico
  • 3University of Wisconsin–Madison
JAMA Neurol. 2015;72(12):1536-1537. doi:10.1001/jamaneurol.2015.3285

To the Editor We are writing in regard to our article published in JAMA Neurology,1 which reported on the relationship between higher insulin resistance and lower cerebral glucose uptake among late middle-aged adults as observed on fludeoxyglucose F 18–labeled positron emission tomography. In addition to main effects of insulin resistance, the study examined the effect of APOE ε4 genotype as well as tested for possible interactions between insulin resistance and APOE ε4. While the study did not find a significant interaction, the report erroneously indicated that the lack of interaction with APOE ε4 was in contrast to an earlier study by Burns et al.2 In fact, the 2 sets of findings are similar, as Burns et al,2 who studied elevated fasting plasma glucose, also did not find an interaction with APOE ε4 genotype.