In 1922, Elmer McCollum, PhD, identified a substance that prevented rickets and identified it as the fourth known “vitamin,” vitamin D.1 For many decades, the importance of this fat soluble vitamin was thought to be restricted to bone metabolism and calcium homeostasis. In 1974, Goldberg published a 2-part article2 hypothesizing a link between vitamin D deficiency and the development of multiple sclerosis (MS). Over 40 years, there have been many publications linking vitamin D deficiency with the development of MS and some research suggesting a protective effect of vitamin D sufficiency. The timing of vitamin D deficiency has been suggested as a critical covariate to its effect on the risk of developing MS.2,3
Greenberg BM. Vitamin D During Pregnancy and Multiple Sclerosis: An Evolving Association. JAMA Neurol. 2016;73(5):498–499. doi:10.1001/jamaneurol.2016.0018
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