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May 2016

Parkinson Disease Risk in Patients With Rosacea

Author Affiliations
  • 1Department of Neurology, Emory University, Atlanta, Georgia
  • 2Department of Human Genetics, Emory University, Atlanta, Georgia
  • 3Division of Neurology, Atlanta Veterans Affairs Medical Center, Atlanta, Georgia
JAMA Neurol. 2016;73(5):501-502. doi:10.1001/jamaneurol.2016.0291

The nonmotor symptoms of Parkinson disease (PD) are well recognized and are thought to often precede the overt manifestations of the motor symptoms.1 Among the cutaneous manifestations of PD, hyperhidrosis, facial flushing, and seborrheic dermatitis are well recognized, and hyperhidrosis and facial flushing are generally considered manifestations of autonomic deregulation. In 2001, Fischer at al2 first noted a relatively high rate of another skin disorder, rosacea, among individuals with PD while investigating the cutaneous manifestations of the disease. Rosacea is a common chronic, inflammatory condition of the skin most easily identified in people with a fair complexion.3 Symptoms range in severity from facial flushing, erythema, telangiectasias, edema, papules, pustules, ocular lesions, and rhinophyma. As noted by Fischer et al, there is an obvious symptomatic overlap between facial flushing that might occur in PD due to dysautonomia and facial flushing experienced by individuals with rosacea. These overlaps complicate investigating the concomitant occurrence of PD and rosacea among individuals with PD.