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Comment & Response
July 2016

Opsoclonus-Myoclonus Syndrome in the Era of Neuronal Cell Surface Antibodies: A Message for Clinicians

Author Affiliations
  • 1Unit of Neurology, Misericordia Hospital, Grosseto, Italy
  • 2Department of Neurology and Psychiatry, “Sapienza” University of Rome, Rome, Italy
JAMA Neurol. 2016;73(7):891. doi:10.1001/jamaneurol.2016.1161

To the Editor We read with interest the study by Armangué and colleagues1 about the clinical and immunological features of opsoclonus-myoclonus syndrome (OMS). Opsoclonus-myoclonus syndrome is a rare movement disorder characterized by involuntary saccades, limb myoclonus, and cerebellar ataxia.2 Its etiology is idiopathic or paraneoplastic (P-OMS). The authors retrospectively investigated a large case series of 114 adult patients with OMS, with the aim of identifying possible clinical clues or antibody biomarkers that could differentiate idiopathic OMS from P-OMS. They found that older age and encephalopathy were significantly associated with P-OMS.

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