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Comment & Response
August 2016

Proton Pump Inhibitors and Dementia Incidence—Reply

Author Affiliations
  • 1German Center for Neurodegenerative Diseases, Bonn, Germany
JAMA Neurol. 2016;73(8):1028-1029. doi:10.1001/jamaneurol.2016.1494

In Reply First, we thank the authors of the letters for their interest and comments concerning our article.1

Keller raises the issue that aluminum-containing antacids may have contributed to the onset of dementia. While the involvement of aluminum in the etiology of dementia still seems to be a matter of debate,2,3 this issue is interesting to examine in further studies. For our analysis, we were not able to include aluminum-containing antacids as these drugs are often not covered by the statutory health insurance in Germany. In a previous primary data analysis by our group, aluminum-containing antacids did not affect the results of proton pump inhibitor (PPI) exposure and dementia risk; however, this aspect was not included in the final publication.4

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