[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 858
Citations 0
Comment & Response
September 2016

The Danger of Not Treating Parkinson Disease Psychosis

Author Affiliations
  • 1University of Florida, Gainesville

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Neurol. 2016;73(9):1156. doi:10.1001/jamaneurol.2016.2280

To the Editor Weintraub et al1 recently published an article in JAMA Neurology on the mortality risk associated with antipsychotic use in Parkinson disease (PD). We do not deny that the collective evidence has strongly suggested that neuroleptics are associated with increased mortality in elderly populations and in the setting of dementia.2,3 The Weintraub et al1 investigation addressed mortality associated with neuroleptic use in PD. The authors did the best they could with the available large data set; however, there was an important limitation. There was no clear comparator group of patients with PD and active psychosis who were not treated with neuroleptics. Additionally, very few patients in the sample were treated with the preferred drug clozapine, which does not worsen parkinsonism.