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Comment & Response
November 2016

Diagnosing Traumatic Encephalopathy Syndrome

Author Affiliations
  • 1Neurosurgery, Hennepin County Medical Center, Minneapolis, Minnesota
JAMA Neurol. 2016;73(11):1373-1374. doi:10.1001/jamaneurol.2016.2802

To the Editor We agree with Reams and colleagues’ review1 finding that because mislocalized phosphorylated tau is neither pathognomic nor causative for clinical neurodegenerative disease, efforts focusing on identification of chronic traumatic encephalopathy in living people are not clinically useful. Chronic traumatic encephalopathy is present in equal incidence in normal healthy elderly individuals as in people with neurodegenerative disease.2 It is a pathologic finding with no clinical correlate.3,4