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The ε4 allele of APOE confers the greatest genetic risk for Alzheimer disease (AD), and recent data implicate brain-iron load as a pathogenic mechanism because ε4 carriage elevates the level of cerebrospinal fluid (CSF) ferritin.1 Controlled for potential confounders like inflammation and bleeding, CSF ferritin level, although not elevated in AD, was associated with longitudinal cognitive performance and the risk of developing AD.1 Herein, we investigate whether CSF ferritin level combines with established AD risk variables in predicting cognitive decline over 7 years in the preclinical phase.
Ayton S, Faux NG, Bush AI. Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers. JAMA Neurol. 2017;74(1):122–125. doi:10.1001/jamaneurol.2016.4406