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JAMA Neurology Clinical Challenge
February 2017

Personality Changes, Executive Dysfunction, and Motor and Memory Impairment

Author Affiliations
  • 1Department of Neurology, Mayo Clinic, Jacksonville, Florida
JAMA Neurol. 2017;74(2):245-246. doi:10.1001/jamaneurol.2016.2782

A 21-year-old woman presented with a 3-year history of progressive depression, bradyphrenia, dyscalculia, and fatigue, necessitating withdrawal from college. She had an ovarian cyst, but her medical history was otherwise unremarkable. There was no history of recreational drug use, tobacco or alcohol consumption, or sexually transmitted diseases. Her mother had died at 32 years of age, after having a chronic neuropsychiatric illness, culminating in a rapidly progressive dementia. A postmortem brain examination reported the presence of multitudinous corpora amylacea, but no specific neuropathological diagnosis was made.