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March 2017

Risk of Multiple Sclerosis After a Clinically Isolated Syndrome: From Magnetic Resonance Imaging to Oligoclonal Bands to Activated T Cells

Author Affiliations
  • 1Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco
JAMA Neurol. 2017;74(3):262-263. doi:10.1001/jamaneurol.2016.5143

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation, demyelination, and neurodegeneration.1-3 The disease is chronic and its reach multifocal. Modern MS diagnosis accordingly rests on the paired tenets of dissemination in time (to distinguish MS from one-time inflammatory events) and dissemination in space (to distinguish MS from syndromes exclusively involving a single neuroanatomic localization).4

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