Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation, demyelination, and neurodegeneration.1-3 The disease is chronic and its reach multifocal. Modern MS diagnosis accordingly rests on the paired tenets of dissemination in time (to distinguish MS from one-time inflammatory events) and dissemination in space (to distinguish MS from syndromes exclusively involving a single neuroanatomic localization).4