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May 2017

Melanopsin Effects on Pupil Responses: Is the Eye the Window to the Weary Soul?

Author Affiliations
  • 1Melbourne Brain Centre, Department of Neurology, Royal Melbourne Hospital at University of Melbourne, Parkville, Melbourne, Victoria, Australia
  • 2Departments of Clinical Neuroscience and Surgery, University of Calgary, Calgary, Alberta, Canada
JAMA Neurol. 2017;74(5):506-508. doi:10.1001/jamaneurol.2016.5385

Multiple sclerosis (MS) remains the major cause of neurologic deficit and disability in young people—those who are establishing themselves professionally and personally and generating a reserve that is to support them and their families throughout the rest of their lives. Disruption at this stage of life has wide-reaching consequences for them personally, their families, and their professional colleagues, affecting all levels of performance. In 2009, there was an estimated 572 312 patients with MS worldwide.1 For noninstitutionalized patients, additional health care costs per year were $24 327 per patient compared with the healthy community, not taking into account lost productivity or early retirement.