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Comment & Response
March 2017

Neurofilament Protein and Antineurofilament Antibodies Following Traumatic Brain Injury

Author Affiliations
  • 1Department of Neurology, University of Wisconsin, Madison
  • 2Kinseiology and Health Education, The University of Texas at Austin, Austin
JAMA Neurol. 2017;74(3):363. doi:10.1001/jamaneurol.2016.5908

To the Editor Shahim et al1 reported the finding that individuals with persistent mild traumatic brain injury (mTBI) (postconcussive syndrome) have increased levels of neurofilament light (NF-L) proteins in their spinal fluid that was suggestive of axonal white matter injury. The increase in NF-L proteins correlated with Rivermead Concussion scores and lifetime concussion events.

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