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Comment & Response
March 2017

Neurofilament Protein and Antineurofilament Antibodies Following Traumatic Brain Injury—Reply

Author Affiliations
  • 1Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden
  • 2Department of Molecular Neuroscience, University College London Institute of Neurology, London, England
JAMA Neurol. 2017;74(3):363-364. doi:10.1001/jamaneurol.2016.5905

In Reply We thank Kornguth for the comment on our article1 on hockey players with persistent symptoms after repetitive mild traumatic brain injury. We showed that a proportion of players have high cerebrospinal fluid levels of neurofilament light protein (NF-L) indicating ongoing axonal injury.1 We found the discovery of autoantibodies to NF-L in the serum of patients with small-cell lung carcinoma associated visual paraneoplastic syndrome intriguing.2 Interestingly, anti-NF antibodies reacting with axons have also been demonstrated in patients with amyotrophic lateral sclerosis, suggesting a possible autoimmune process.3