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Comment & Response
May 2017

Circulating Interleukin 6 in Parkinson Disease

Author Affiliations
  • 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
  • 2Stress Research Institute, Stockholm University, Stockholm, Sweden
JAMA Neurol. 2017;74(5):607-608. doi:10.1001/jamaneurol.2017.0037

To the Editor Qin et al1 have performed a meta-analysis of the observational association of circulating cytokines with Parkinson disease (PD) status, finding elevated levels of interleukin 6 and other cytokines among patients with PD compared with healthy control participants. Meta-analyses of observational outcomes, however, are prone to biases because of unresolvable confounding, requiring cautious interpretation.2

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