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Comment & Response
May 2017

Congenital Zika Virus Infection: Beyond Neonatal Microcephaly

Author Affiliations
  • 1Antônio Pedro University Hospital, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
JAMA Neurol. 2017;74(5):610. doi:10.1001/jamaneurol.2017.0048

To the Editor In their timely description on the major central nervous system lesions caused by Zika virus (ZIKV) congenital infection, Melo et al1 reported on the neuroimaging, laboratory, and histological findings among 11 children born with ZIKV congenital infection syndrome. Aside from microcephaly and its associated cortical malformations, the authors also described the presence of arthrogryposis among 3 children. In the pathological findings, they observed fewer than expected motor nerve cells in the spinal cord in 1 of the newborns who died after birth.

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