With the extent of the recent Ebola virus disease (EVD) epidemic in West Africa (including >28 000 cases and ≤17 000 survivors), many aspects of Ebola virus have become clearer, including acute manifestations, sequelae, and the possibility of relapse and persistence.1 Neurologic complications are becoming more commonly recognized in EVD during the acute phase, with long-term sequelae.2- 4 More remarkable, however, is the potential for persistence and relapse of EVD in the central nervous system (CNS), as in the case of a nurse who developed meningoencephalitis with seizures, cranial nerve involvement, and radiculitis 9 months after EVD recovery.5 Ebola virus was recovered from the cerebrospinal fluid (CSF) at higher levels than from the blood, indicating viral replication in the CNS.5 This case reveals the need to determine the role of the CNS as a potential reservoir for Ebola virus after initial clinical recovery.
Bridgette Jeanne Billioux, Avindra Nath, Eric J. Stavale, Joseph Dorbor, Mosoka P. Fallah, Michael C. Sneller, Bryan R. Smith, . Cerebrospinal Fluid Examination in Survivors of Ebola Virus Disease. JAMA Neurol. 2017;74(9):1141–1143. doi:10.1001/jamaneurol.2017.1460