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Comment & Response
October 2017

Light Therapy Promoting Dopamine Release by Stimulating Retina in Parkinson Disease—Reply

Author Affiliations
  • 1Department of Neurology, Massachusetts General Hospital, Boston
  • 2Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts
  • 3Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
  • 4Department of Neurology, Northwestern University, Chicago, Illinois
JAMA Neurol. 2017;74(10):1268-1269. doi:10.1001/jamaneurol.2017.1909

In Reply We read with interest the Letter to the Editor by Li and Tian. Their letter centers on the potential novel mechanism of action of light therapy in Parkinson disease (PD). Specifically, they highlight the possibility that light therapy may promote dopamine release by stimulating cells within the retina, which translates to improvements of PD symptoms. We agree that this is a sound scientific hypothesis based on the current understanding of the intricate relationship between the retinal dopaminergic function in PD and the circadian system.

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