Clinicians have long suspected that a patent foramen ovale (PFO) or an atrial septal aneurysm can be a nidus or conduit for thromboembolism and, therefore, a risk factor for stroke. Epidemiological studies have generally found an association between PFO and ischemic stroke.1 As a result, investigators have published results from 5 randomized clinical trials of percutaneous PFO closure in patients with ischemic stroke since 2012.1-5
Kamel H. Evidence-Based Management of Patent Foramen Ovale in Patients With Ischemic Stroke. JAMA Neurol. 2018;75(2):147–148. doi:10.1001/jamaneurol.2017.3982
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