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April 16, 2018

Preventing Sudden Unexpected Death in Epilepsy

Author Affiliations
  • 1Department of Neurology, New York University School of Medicine, New York
  • 2Department of Clinical Neurosciences, Centre Hospitalo-Universitaire Vaudois, Lausanne, Switzerland
  • 3Epilepsy Institute, Lyon, France
JAMA Neurol. Published online April 16, 2018. doi:10.1001/jamaneurol.2018.0400

People with epilepsy face a significantly increased risk of death from direct effects of seizures as well as indirect effects of epilepsy and its treatment. Sudden death is approximately 25-fold higher among people with epilepsy compared with those in the general population, with the greatest risk due to sudden unexpected death in epilepsy (SUDEP).1 Despite intensive research leading to animal models as well as epidemiologic and clinical studies to better define mechanisms and risk factors, SUDEP continues to be the leading cause of epilepsy-related death.

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