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Images in Neurology
October 2018

Selenium Toxicity Associated With Reversible Leukoencephalopathy and Cortical Blindness

Author Affiliations
  • 1Department of Immunology, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southhampton, England
  • 2National Institute for Health Research Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southhampton, England
  • 3Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southhampton, England
JAMA Neurol. 2018;75(10):1282-1283. doi:10.1001/jamaneurol.2018.1669

A woman in her early 50s presented with 2 months of progressive cognitive impairment and visual loss. Her visual acuity was reduced to hand movements bilaterally and she was unable to read numbers or trace lines on Ishihara plates. Her flash and pattern electroretinogram and occipital pattern visual evoked potentials results were normal. Coronal fluid-attenuated inversion recovery magnetic resonance imaging (MRI) scans showed extensive confluent symmetrical occipital predominant white matter abnormalities (Figure 1A).

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