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Comment & Response
September 2018

Retinoids and Amyotrophic Lateral Sclerosis

Author Affiliations
  • 1Department of Neurology, Hospital Sierrallana-Instituto de Investigación Sanitaria, Centro Investigación Biomédica en Red Enfermedades (CIBERNED), Santander, Spain
  • 2Neurosciences Area, Biodonostia Health Research Institute, CIBERNED, Torrelavega, Spain
  • 3Department of Neurology, University Hospital Donostia, Biodonostia Health Research Institute, CIBERNED, San Sebastián, Spain
  • 4Department of Neurosciences, University of the Basque Country Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, CIBERNED, San Sebastián, Spain
JAMA Neurol. 2018;75(9):1153. doi:10.1001/jamaneurol.2018.2242

To the Editor We read with great interest the article by Rosenbohm and colleagues.1 They conducted a case-control study and reported that retinol-binding protein 4 had an inverse association with both risk for amyotrophic lateral sclerosis (ALS) and disease prognosis. Although we agree with the relevance of the reported results and their interpretation, we would like to comment on 2 issues that might also correlate with these findings.