[Skip to Content]
[Skip to Content Landing]
Research Letter
December 2018

Epidural Spinal Cord Stimulation Training and Sustained Recovery of Cardiovascular Function in Individuals With Chronic Cervical Spinal Cord Injury

Author Affiliations
  • 1Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville
  • 2Frazier Rehab Institute, Louisville, Kentucky
  • 3Department of Neurosurgery, School of Medicine, University of Louisville, Louisville, Kentucky
  • 4Division of Cardiovascular Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky
JAMA Neurol. 2018;75(12):1569-1571. doi:10.1001/jamaneurol.2018.2617

Cervical spinal cord injury (SCI) profoundly disrupts the cardiovascular and autonomic systems, severely diminishing overall health and quality of life.1 Mitigation of unstable blood pressure is a high priority in care for individuals with chronic SCI; however, to our knowledge, no existing therapies have demonstrated the ability to resolve chronic cardiovascular dysfunction.2 Hypotension was acutely resolved in 4 individuals with chronic, cervical motor-complete SCI with customized epidural stimulation configurations targeted for cardiovascular function (CV-scES).3 We evaluated the outcome of CV-scES when used as daily CV-scES training to target chronic orthostatic hypotension.