Cervical spinal cord injury (SCI) profoundly disrupts the cardiovascular and autonomic systems, severely diminishing overall health and quality of life.1 Mitigation of unstable blood pressure is a high priority in care for individuals with chronic SCI; however, to our knowledge, no existing therapies have demonstrated the ability to resolve chronic cardiovascular dysfunction.2 Hypotension was acutely resolved in 4 individuals with chronic, cervical motor-complete SCI with customized epidural stimulation configurations targeted for cardiovascular function (CV-scES).3 We evaluated the outcome of CV-scES when used as daily CV-scES training to target chronic orthostatic hypotension.
Harkema SJ, Legg Ditterline B, Wang S, et al. Epidural Spinal Cord Stimulation Training and Sustained Recovery of Cardiovascular Function in Individuals With Chronic Cervical Spinal Cord Injury. JAMA Neurol. 2018;75(12):1569–1571. doi:10.1001/jamaneurol.2018.2617
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