In Reply We read with interest the comments by Fifel on our histologic study of the circadian system in parkinsonism, although we would like to highlight some inaccuracies in his interpretation of the neuropathological findings. We identified a clear, distinct pattern of neuropathological involvement in Parkinson disease (PD) suggesting that the neuroanatomical site of circadian disruption is located in the suprachiasmatic nucleus (SCN).1
De Pablo-Fernández E, Warner TT, Holton JL. Neuropathology of Circadian Alterations in Parkinson Disease—Reply. JAMA Neurol. 2019;76(1):115–116. doi:10.1001/jamaneurol.2018.3758
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