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Comment & Response
January 2019

Neuropathology of Circadian Alterations in Parkinson Disease—Reply

Author Affiliations
  • 1Queen Square Brain Bank for Neurological Disorders, University College London Institute of Neurology, London, England
  • 2Reta Lila Weston Institute, University College London Institute of Neurology, London, England
JAMA Neurol. 2019;76(1):115-116. doi:10.1001/jamaneurol.2018.3758

In Reply We read with interest the comments by Fifel on our histologic study of the circadian system in parkinsonism, although we would like to highlight some inaccuracies in his interpretation of the neuropathological findings. We identified a clear, distinct pattern of neuropathological involvement in Parkinson disease (PD) suggesting that the neuroanatomical site of circadian disruption is located in the suprachiasmatic nucleus (SCN).1

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