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Comment & Response
January 2019

On Mediation Models in Clinical Neurology Studies

Author Affiliations
  • 1Department of Psychiatry and Medical Psychology, Universidade Federal de São Paulo, São Paulo, Brazil
  • 2Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany
  • 3Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
  • 4Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada
JAMA Neurol. 2019;76(1):116-117. doi:10.1001/jamaneurol.2018.3884

To the Editor We applaud the recent work of Kim et al,1 including their use of mediation modeling, a technique that is relatively new to the field and is used to advance thinking about associations between variables beyond bivariate associations and to uncover potential mechanisms. As this technique becomes increasingly popular, 2 considerations are important.