To the Editor We applaud the recent work of Kim et al,1 including their use of mediation modeling, a technique that is relatively new to the field and is used to advance thinking about associations between variables beyond bivariate associations and to uncover potential mechanisms. As this technique becomes increasingly popular, 2 considerations are important.
Cogo-Moreira H, Swardfager W. On Mediation Models in Clinical Neurology Studies. JAMA Neurol. 2019;76(1):116–117. doi:10.1001/jamaneurol.2018.3884
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