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Comment & Response
March 4, 2019

Time Is Brain and Spine—Reply

Author Affiliations
  • 1Department of Neurology, MS Center ErasMS, Erasmus MC, Rotterdam, the Netherlands
JAMA Neurol. 2019;76(5):623-624. doi:10.1001/jamaneurol.2019.0149

In Reply We agree with Obeidat that the overall prognosis for patients with multiple sclerosis (MS) is getting better. This is partly because of earlier treatment with disease-modifying therapies (DMT), but it is also due to changes in the MS criteria over time; the consecutive criteria for MS have gradually become less strict and have led to a better prognosis in the total group of patients with MS.1

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