In Reply We agree with Obeidat that the overall prognosis for patients with multiple sclerosis (MS) is getting better. This is partly because of earlier treatment with disease-modifying therapies (DMT), but it is also due to changes in the MS criteria over time; the consecutive criteria for MS have gradually become less strict and have led to a better prognosis in the total group of patients with MS.1
van der Vuurst de Vries RM, Hintzen RQ. Time Is Brain and Spine—Reply. JAMA Neurol. 2019;76(5):623–624. doi:https://doi.org/10.1001/jamaneurol.2019.0149
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