The 20th century marked the rise of status epilepticus. Previously thought to be a relatively obscure clinical phenomenon, by the beginning of the century, status epilepticus was recognized as a unique, important, and highly morbid form of seizure.1 The advent of electroencephalography followed by the discovery of diazepam in the second half of the century revolutionized our ability to identify, characterize, and treat status epilepticus. We have since refined our understanding of the disease, placing increased focus on rapid treatment as being critical to achieving seizure termination, avoiding pharmacoresistance, preventing neuronal injury, and improving clinical outcomes.
Guterman EL, Betjemann JP. Status Epilepticus Mortality—Improving or Status Quo? JAMA Neurol. 2019;76(8):885–886. doi:10.1001/jamaneurol.2019.0844
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