A 42-year-old man presented with a 2-month history of persistent muscle twitching in his abdomen and bilateral calves during wakefulness and sleep accompanied with excessive sweating, as well as mild bilateral lower extremity weakness after prolonged walking. The patient denied confusion, memory problems, hallucinations, and sleep disturbance. He had psoriasis for 30 years, for which he was taking steroids intermittently, and hypothyroidism for 4 years, for which he was taking levothyroxine. His family history was unremarkable. His examination results were significant for psoriatic skin lesions and purple stria in the abdomen and both calves. Undulating wavelike movements were visible on the muscle surface of the abdomen and calves (Video). The remaining general and neurological examination results were normal. Laboratory test results, including creatine kinase, thyrotropin, antinuclear antibodies, paraneoplastic antibodies (includes Hu, Yo, Ri, CV2, Ma2, and amphiphysin antibodies), were normal. Chest computed tomography results were normal.
Qian M, Qin L, Guan H. A Case of Muscle Twitching With Psoriasis. JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.1937
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: