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Comment & Response
July 15, 2019

Dysregulation of the Reward and Learning Systems in Tourette Syndrome

Author Affiliations
  • 1Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
  • 2Department of Psychiatry, Psychotherapy, and Psychosomatics, Johanniter Krankenhaus, EVKLIN, Oberhausen, Germany
JAMA Neurol. 2019;76(9):1124. doi:10.1001/jamaneurol.2019.2027

To the Editor In their cohort study, Brander et al1 observed an increased risk of metabolic and cardiovascular diseases in patients with Tourette syndrome (TS) and chronic tic disorder. This risk was even higher in patients with comorbid attention-deficit/hyperactivity disorder. Interestingly, metabolic and cardiovascular risks were already present at an early stage of the disorder and were actually decreased in patients that used antipsychotic medication for a longer time. These data are relevant for the field because they were previously unknown in this form and must be considered in the future care of these patients.

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