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Research Letter
July 29, 2019

Association of Personalized Blood Pressure Targets With Hemorrhagic Transformation and Functional Outcome After Endovascular Stroke Therapy

Author Affiliations
  • 1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut
  • 2Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
JAMA Neurol. 2019;76(10):1256-1258. doi:10.1001/jamaneurol.2019.2120

The loss of cerebral autoregulation in the acute phase of ischemic stroke leaves patients vulnerable to changes in blood pressure (BP),1 potentially resulting in additional injury from relative hypoperfusion or hyperperfusion. We have shown that near-infrared spectroscopy can be used to identify and track the BP range in individual patients at which autoregulation is optimally functioning.2 Such an autoregulation-derived, personalized BP range may provide a favorable physiologic environment for the injured brain. In this study, we used a novel approach to define and trend limits of autoregulation (LA) to determine patient-specific, dynamic BP targets. The aim of this study was to assess the feasibility of determining personalized BP targets as well as the association of deviating from these targets with radiographic and clinical outcomes.