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Comment & Response
August 12, 2019

Mischaracterization of Spaceflight-Associated Neuro-Ocular Syndrome—Reply

Author Affiliations
  • 1Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston
  • 2Department of Orthopedic Surgery, University of California, San Diego, La Jolla
JAMA Neurol. Published online August 12, 2019. doi:10.1001/jamaneurol.2019.2379

In Reply We thank Williams and Malm for their interest in our Viewpoint1 on structural brain changes in astronauts, which we have termed hydrocephalus associated with long-term spaceflight (HALS). As Williams and Malm indicate, we,2 along with others,3 have documented an 11% to 14% increase (or approximately a mean [SD] increase of 2.9 [3.0] mL) in ventricular volume following long-duration spaceflights of 6 months.

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