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Comment & Response
October 14, 2019

Cautious Interpretation of Observational Data

Author Affiliations
  • 1Department of Neurology, Centro Hospitalar Universitário de São João, Porto, Portugal
  • 2Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England
JAMA Neurol. Published online October 14, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3456

To the Editor We read the article by Harding and colleagues1 regarding escalation vs early intensive approaches in treating patients with multiple sclerosis (MS). We agree that treating MS early and aggressively to halt disease from the start sounds attractive. In fact, there are clinical trial data that find an association of an early vs delayed start of a higher-efficacy therapy with sustained relapse rate reductions.2 However, there are limitations in interpreting observational data, especially in MS cohorts, that were not fully addressed in the article.

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