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Comment & Response
October 14, 2019

Cautious Interpretation of Observational Data—Reply

Author Affiliations
  • 1School of Medicine, Institute of Psychological Medicine and Clinical Neuroscience, Heath Park, Cardiff University, Cardiff, Wales
  • 2Helen Durham Centre for Neuroinflammatory Disease, Heath Park, University Hospital of Wales, Cardiff, Wales
  • 3Department of Neurology, Royal Gwent Hospital, Newport, England
JAMA Neurol. 2019;76(12):1519-1520. doi:10.1001/jamaneurol.2019.3459

In Reply We thank Soares-dos-Reis and Messina for their comments on our article.1 We agree that clinical observational data are often limited and require cautious interpretation. For this reason, we have used our preliminary observational data to collaborate with other centers and establish a prospective trial to address this important question (NCT03535298).

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