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Research Letter
October 28, 2019

Coexistence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies in Adult and Pediatric Patients

Author Affiliations
  • 1Department of Neurology, Mayo Clinic, Rochester, Minnesota
  • 2Department Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
  • 3Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, Minnesota
  • 4Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota
JAMA Neurol. 2020;77(2):257-259. doi:10.1001/jamaneurol.2019.3656

Myelin oligodendrocyte glycoprotein (MOG)–IgG is a biomarker associated with central nervous system–demyelinating disorders termed MOG-IgG–associated disorders. These disorders have overlapping clinical features, including optic neuritis and myelitis, with aquaporin-4 (AQP4)–IgG–positive neuromyelitis optica spectrum disorders. These disorders are hypothesized to be biologically distinct; AQP4-IgG–positive neuromyelitis optica spectrum disorders are autoimmune astrocytopathies, whereas MOG-IgG–associated disorders are postulated to be autoimmune oligodendrocytopathies.1 Despite their immunopathogenic differences, there are rare reports of patients with dual positivity of MOG-IgG and AQP4-IgG.2,3 We aimed to determine the frequency, sex ratio, and coexistence of glial antibodies (AQP4-IgG and MOG-IgG) in adults and children undergoing evaluation for suspected central nervous system–demyelinating diseases.

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