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Images in Neurology
November 4, 2019

Distinctive Magnetic Resonance Imaging Findings in IgLON5 Antibody Disease

Author Affiliations
  • 1Department of Neurology, Third Xiangya Hospital of Central South University, Changsha, China
  • 2Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
JAMA Neurol. Published online November 4, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3638

A Chinese woman in her 40s presented to the emergency department with a reduced level of consciousness. She had a 5-year history of depression with apathy, insomnia, and suicidal tendencies, which was refractory to paroxetine and buspirone. For a few weeks prior to admission, her husband had noticed prominently nocturnal dyspnea. One week before admission, she developed headache, fever, and vomiting, which persisted until hospitalization. Soon after admission, she had a generalized seizure, and within 24 hours, she underwent intubation for status epilepticus.

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