[Skip to Navigation]
Views 1,133
Citations 0
December 9, 2019

Potential of Intra-arterial Urokinase After Incomplete Mechanical Thrombectomy—Looking Back, Moving Forward

Author Affiliations
  • 1Department of Neurology, UTHealth McGovern Medical School, Houston, Texas
JAMA Neurol. 2020;77(3):298-299. doi:10.1001/jamaneurol.2019.3984

Complete and rapid revascularization can dramatically reduce disability after large-vessel occlusion (LVO) acute ischemic stroke (AIS).1 With modern mechanical thrombectomy (MT), we now have a safe and effective method to recanalize occluded cerebral vessels, and in this issue of JAMA Neurology, Kaesmacher et al2 move the field 1 step closer to achieving the goal of complete revascularization. Cohort studies have demonstrated that even among patients who achieve substantial reperfusion, defined as a Thrombolysis in Cerebral Infarction grade of 2b or greater, those who achieve the highest grades of reperfusion have quantifiably improved outcomes, but only a minority are able to achieve these highest grades.3 As such, one of the primary targets for improvement in MT is finding reliable means of achieving near-perfect reperfusion.

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words