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Comment & Response
February 3, 2020

Alzheimer Disease, Biomarkers, and Clinical Symptoms—Quo Vadis?

Author Affiliations
  • 1Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, School of Medicine and Dentistry, Division of Geriatric Medicine, Departments of Medicine and Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada
  • 2University of Calgary, Calgary, Alberta, Canada
  • 3University of Alberta, Edmonton, Alberta, Canada
JAMA Neurol. Published online February 3, 2020. doi:10.1001/jamaneurol.2019.4959

To the Editor We read with interest the article from Jack et al,1 and its Editorial that shows that the prevalence of 2 neuropathologic hallmarks of Alzheimer disease (AD), β-amyloid plaques, and neurofibrillary tangles is much higher than the prevalence of 3 associated clinical manifestations: mild cognitive impairment, dementia, and probable AD.1 Notably, this asymptomatic prevalence of brain load biomarker increased by 3 times in those 85 years and older.1

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