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Comment & Response
May 4, 2020

Importance of the Intention-to-Treat Principle—Reply

Author Affiliations
  • 1Semmes Murphey Neurologic and Spine Clinic, Memphis, Tennessee
  • 2Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee
  • 3Second Department of Neurology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece
JAMA Neurol. Published online May 4, 2020. doi:10.1001/jamaneurol.2020.0866

In Reply We thank Nagel et al for their thoughtful comments on our article on medical management vs mechanical thrombectomy (MT) for mild strokes.1 We agree that medically treated patients with large vessel occlusion (LVO) with mild deficits can potentially experience neurological deterioration and rescue therapy may be required. We do not know how often this occurs or if there are factors that might increase or decrease this rate.

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