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May 18, 2020

Risk of Neuroinflammatory Adverse Events With Tumor Necrosis Factor Inhibitor Treatment

Author Affiliations
  • 1Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco
  • 2Rheumatology, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco
JAMA Neurol. 2020;77(8):933-935. doi:10.1001/jamaneurol.2020.1160

Tumor necrosis factor (TNF) inhibitors have been widely used for the treatment of autoimmune disease since 1998, when the first biological agents were licensed in the United States.1 Several biosimilar versions are now available.2 These therapies target the TNF receptor (infliximab, adalimumab, certolizumab pegol, and golimumab) or its soluble form (etanercept) to modulate immune function.

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