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Research Letter
August 31, 2020

Long-term Outcomes in Patients With Myelin Oligodendrocyte Glycoprotein Immunoglobulin G–Associated Disorder

Author Affiliations
  • 1Department of Neurology, Mayo Clinic, Jacksonville, Florida
  • 2Department of Neurology, Mayo Clinic, Rochester, Minnesota
  • 3Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota
  • 4Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
JAMA Neurol. 2020;77(12):1575-1577. doi:10.1001/jamaneurol.2020.3115

Data on long-term outcomes of patients with myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG)–associated disorder (MOGAD) are scarce.1,2 We report outcomes in a single-institution cohort with long-term follow-up.

We retrospectively identified 11 adult and 18 pediatric (onset age younger than 18 years) Mayo Clinic patients from January 1, 2000, through May 31, 2019, with (1) MOGAD clinical phenotype3; (2) MOG-IgG 1 seropositivity (median titer, 1:100; range, 1:20-1:1000; 8 of 13 serial samples persistently positive)3; and (3) 9 or more years’ follow-up from onset. The study was approved by the Mayo Foundation Institutional Review Board (IRB No. 08.006647). Written informed consent was provided by patients or parents.

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