A 73-year-old man was admitted with intractable hiccups. His history was notable for lymphoplasmacytic lymphoma (LPL) diagnosed several years prior when he presented with fatigue and was found to have serum IgM κ monoclonal protein with an M spike and a hypercellular bone marrow biopsy with lymphoplasmacytic features. He was initially treated with a chemotherapeutic regimen of rituximab, cyclophosphamide, vincristine, and prednisone. In the setting of progressive disease, he ultimately underwent autologous peripheral blood stem cell transplant. Serial monitoring thereafter revealed normal complete blood cell counts.
Mustafa R, Neth BJ, Stitt D. Bilateral Vagus Nerve Enhancement in a Patient With Leptomeningeal Lymphoplasmacytic Lymphoma Presenting with Intractable Hiccups. JAMA Neurol. 2021;78(4):493–494. doi:10.1001/jamaneurol.2020.4830
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